IV Primary treatment of ovarian carcinoma Combination regimen: 135 mg/m
3 administered over 24 hr, followed by cisplatin 75 mg every 3 wk. Paclitaxel should be administered before cisplatin.
Secondary treatment of ovarian carcinoma 175 mg/m
3 administered IV over 3 hr every 3 wk in patients w/ metastatic carcinoma of the ovary or breast after the failure of 1st-line or subsequent chemotherapy.
Palliative treatment of advanced NSCLC175 mg/m
3 over a period of 3 hr followed by platinum compd w/ 3-wk interval between courses. Should not be readministered until neutrophil is at least 1,500/mm
3 & platelet is at least 100,000/mm
3.
Patient who experience severe neutropenia (neutrophil count <500/mm3) or moderate to severe peripheral neuropathy Dose reduction of 20% for subsequent courses. All patients must be premedicated w/ corticosteroids, antihistamines & H
2 antagonists prior to paclitaxel administration eg, dexamethasone 20 mg orally approx 12 & 6 hr before paclitaxel, promethazine 25 IV 30-60 min before paclitaxel.
Sign Out
